MicroRNA - 134 activity in somatostatin interneurons regulates H - Ras localization by repressing

MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9.

MicroRNA-134 (miR-134) serves as a widely accepted model for microRNA function in synaptic plasticity. In this model, synaptic activity stimulates miR-134 expression, which then regulates dendrite growth and spine formation. By using a ratiometric microRNA sensor, we found, unexpectedly, that miR-134 activity in cortical neurons was restricted to interneurons. Using an assay designed to trap mi...

MicroRNA - 134 activity in somatostatin interneurons regulates H - Ras localization

MicroRNA - 134 activity in somatostatin interneurons regulates

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Regulation of Ras/RAF signaling by DiRas3 1 The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF and Regulates Localization, Dimerization and Kinase Activity of C-RAF*

Background: The tumor suppressor DiRas3 interferes with the Ras/MAPK mitogenic cascade. Results: DiRas3 associates with H-Ras and CRAF and regulates localization, dimerization and kinase activity of C-RAF. Conclusion: DiRas3 regulates the Ras/MAPK cascade at the level of Ras/RAF signal transmission. Significance: Learning how DiRas3 affects the Ras/MAPK signaling is crucial for understanding of...

CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide Y-expressing GABAergic interneurons.

Cortical GABAergic interneurons are divided into various subtypes, with each subtype contributing to rich variety and fine details of inhibition. Despite the functional importance of each interneuron subtype, the molecular mechanisms that contribute to sorting them to their appropriate positions within the cortex remain unclear. Here, we show that the chemokine receptor CXCR4 regulates the regi...